Make a claim about how PDC deficiency affects the amount of NADH produced by glycolysis AND the amount of NADH produced by the Krebs (citric acid) cycle in a cell. Provide reasoning to support your claims based on the position of the PDC -catalyzed reaction in the sequence of the cellular respiration pathway.

PDC deficiency directly regulates the concentration of NADH produced during glycolysis and Krebs cycle as it affects the concentration of acetyl CoA that also participate in the two vital processes.

Krebs cycle occurs in the mitochondrial matrix. This process derives energy from metabolic substrates like carbohydrates, fatty acids, and amino acids. Malfunctioning of the Krebs cycle deprives energy from the body. Moreover, in PDC deficiency oriented Krebs cycle the carbohydrate substrate after the breakdown does not get converted into acetyl CoA. This leads to the increase in build up of the lactate and alanine. Lack of energy production during Krebs and glycolysis cycles result in symptoms of lethargy, stress, higher intake of carbohydrates, and tachypnea.

Learn more about Krebs cycle:

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Answerin vivo exposure;